Lipid Composition, Fatty Acids and Sterols in the Seaweeds Ulva armoricana, and Solieria chordalis from Brittany (France): An Analysis from Nutritional, Chemotaxonomic, and Antiproliferative Activity Perspectives

Melha Kendel (1) , Gaëtane Wielgosz-Collin (2) , Samuel Bertrand , Christos Roussakis (2) , Nathalie Bourgougnon (1) , Gilles Bedoux (1)

1 LBCM - Laboratoire de Biotechnologie et Chimie Marines
2 IICiMed - Cibles et Médicaments des Infections et de l'Immunité

Lipids from the proliferative macroalgae Ulva armoricana (Chlorophyta) and Solieria chordalis (Rhodophyta) from Brittany, France, were investigated. The total content of lipids was 2.6% and 3.0% dry weight for U. armoricana and S. chordalis, respectively. The main fractions of S. chordalis were neutral lipids (37%) and glycolipids (38%), whereas U. armoricana contained mostly neutral lipids (55%). Polyunsaturated fatty acids (PUFA) represented 29% and 15% of the total lipids in U. armoricana and S. chordalis, respectively. In both studied algae, the phospholipids were composed of PUFA for 18%. In addition, PUFA were shown to represent 9% and 4.5% of glycolipids in U. armoricana and S. chordalis, respectively. The essential PUFA were 16:4n-3, 18:4n-3, 18:2n-3, 18:2n-6, and 22:6n-3 in U. armoricana, and 20:4n-6 and 20:5n-3 in S. chordalis. It is important to notice that six 2-hydroxy-, three 3-hydroxy-, and two monounsaturated hydroxy fatty acids were also 5607 identified and may provide a chemotaxonomic basis for algae. These seaweeds contained interesting compounds such as squalene, α-tocopherol, cholest-4-en-3-one and phytosterols. The antiproliferative effect was evaluated in vitro on human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) with an IC50 of 23 μg/mL for monogalactosyldiacylglycerols isolated from S. chordalis and 24 μg/mL for digalactosyldiacylglycerols from U. armoricana. These results confirm the potentialities of valorization of these two species in the fields of health, nutrition and chemotaxonomy.

Keywords: phospholipids; glycolipids; polyunsaturated fatty acids; Ulva armoricana; Solieria chordalis; fatty acids; chemotaxonomy; human lung cancer; hydroxy fatty acids; sterols

Domains: Medicinal Chemistry; Botanics

Melha Kendel, Gaëtane Wielgosz-Collin, Samuel Bertrand, Christos Roussakis, Nathalie Bourgougnon, et al.. Lipid Composition, Fatty Acids and Sterols in the Seaweeds Ulva armoricana, and Solieria chordalis from Brittany (France): An Analysis from Nutritional, Chemotaxonomic, and Antiproliferative Activity Perspectives. Marine drugs, 2015, 13 (9), pp.5606-5628. ⟨10.3390/md13095606⟩. ⟨hal-01370285⟩