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Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos

Abstract : Objective To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vera cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, MCF-7, K562, CEM-SS and WEHI-3B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process.
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https://hal.archives-ouvertes.fr/hal-02093105
Contributor : Karim Belghit <>
Submitted on : Monday, April 8, 2019 - 4:23:27 PM
Last modification on : Monday, August 24, 2020 - 10:36:45 AM

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Zalilawati Mat Rashid, Abdul M. Ali, Philippe Douzenel, Nathalie Bourgougnon, Khozirah Shaari, et al.. Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Asian Pacific Journal of Tropical Biomedicine, 2018, 8 (11), pp.554-564. ⟨10.4103/2221-1691.245971⟩. ⟨hal-02093105⟩

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